Antibacterial Activity of Noni Fruit Extract (Morinda citrifolia) against Staphylococcus aureus ATCC 25923 and Methicillin Resistant Staphylococcus aureus (MRSA)

Background: Noni fruit (Morinda citrifolia L.) has long been known by the people of Indonesia, especially Java, Sumatra, and Borneo. is also widely used as traditional medicine in almost all islands Indonesia. to have antibacterial activity against Staphylococcus aureus MRSA (Methicillin-Resistant aureus). The noni due phytochemical compounds found fruit, such iridoids, flavonoids, fatty acids, lignans, anthraquinone vitamins, trace elements. Objective: This study aimed determine methanol extract Methods: research was an experiment using a well-diffusion method aureus) vitro. Minimum Bactericidal Concentration (MBC) values were determined diffusion method. MBC suspension streaking Muller Hinton broth on mac Conkey agar plate. Five concentrations for method, obtained from serial dilution distilled water. 100%, 50%, 25%, 12.5%, 6.25%, respectively. positive control this erythromycin 15 µg, vancomycin 30 µg. Results: 6,25% 3,13% Conclusion: shows higher MRSA. average diameter inhibition zone each specific case 0 – 26.64 mm 24.63 Therefore, further needed developing oral or topical antibiotic.